Scientific Presence at Society of Toxicology 2019

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Nonclinical Developmental Considerations for Cell & Gene Therapy

Paul Byrne, PhD, & Brian McIntosh, PhD
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A Graph is Worth a Thousand Data Points (SEND)

Megan Bausman, BS & MBA, & Mikayla Simons
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Evaluation of AAV-Based Gene Delivery to Retinal Cells in Histological Sections in Animal Toxicity Studies | Gennadly Bondarenko

Development of a Validation Strategy for GLP-Compliant Execution of ELISpot Assays Intended for Quantitation of Antigen-Specific Cellular Immune Responses | Haiyan Chu

Ocular Toxicity Associated with a Class of PI3Kβ Selective Inhibitor | Julia Detert & Peter Thomford

Supportive Care for Animals on Toxicology Studies: An Industrial Benchmark Survey | Amy Kamholz

Optimized Methods for Irradiation and Chemical Myeloablation in NSG Mice Prior to Human Hematopoietic Stem Cell (Gene) Therapy | Lakshmi Kelamangalath

A Unique Comparison of Three Intrathecal Administration Techniques for Non-Systemic Delivery of CNS-Targeting Antisense Oligonucleotides in Cynomonglus Monkeys for the Benefit of the 3R's | Sven Korte, S. Bassett, Florian Ludwig, M. Niehoff, J. Luft, F. Lunge, A. Von Keutz, T. Voß

Physiologically-Based Pharmacokinetic Modeling for Optimization of Sustained Release Buccal Formulations of Clonidine | Mingguang Li

Two Cases of Lumbar Spinal Cord Infarction in Cynomolgus Monkeys Associated with Intrathecal Bolus Administration | Florian Timo Ludwig

MRI-Guided Stereotactic Infusion of Gene Therapy Products in Cynomolgus Monkeys | Florian Timo Ludwig

Techniques for Non-Systemic Delivery of CNS-Targeting Antisense Oligonucleotides in Cynomolgus Monkeys for the Benefit of the 3Rs | Florian Timo Ludwig

Development of Human Proximal Tubule-Chip for Assessment of Potential Renal Transporter-Based Drug-Drug Interactions | Gang Luo

Applying the Appropriate Assay Format for Cytokine Release Assays to Deliver the Appropriate Interpretation of Safety Risks | James Munday

The Impact of High Heart Rates on Quantitative Electrocardiography Evaluation: Can Overlapping P and T Waves Be Accurately Assessed? | Ian Mogenson

Sensitivity of Micro-Computed Tomography (micro-CT) Imaging to Visualize Skeletal Variations and Malformations in Embryo-Fetal Development Toxicity Studies | Arun Tartiparthi

Sensitivity of Fertility Assessment in the Long-Tailed Macaque (Cynomolgus Monkey,Macaca fascicularis) in Nonclinical Safety Studies | Gerhard Weinbauer

Placental Transfer of 125iodinated Humanized Immunoglobulin G2Δs in the Cynomolgus Monkey | Gerhard Weinbauer & Michael Potchoiba

Toxicological Evaluation of Carboplatin Using an In Vivo Gene Mutation Assay (Pig-a) in Rodents | Javed Bhalli

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