Intelligent Screening: 
Evolving Your Data Approaches & Drivers

Join us at the beautiful Rudding Park estate for an exclusive symposium exploring DMPK and Genetic Toxicology screening data drivers and approaches. 

Whilst here, plan to come a little early or stay a little late to enjoy a tour of the expanded metabolism laboratory at Covance in Harrogate. 

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 Rudding Park estate
10:00  Metabolism Covance Lab Tour - optional

Noon  Kickoff Luncheon

13:30  Block I
  • Patrick Soubayrol, PhD (Sanofi): 
    • The Sanofi strategy for screening and candidate selection reading across in vitro and in vivo 
  • Lisa Patterson, BSc (Covance): 
    • In Vivo fast PK screening:  formulation strategies, cassette dosing, data output and link to modelling
  • Rachel Sayer, PhD (Covance): 
    • Strengths and limitations of the CaCo-2 permeability assay: A CRO perspective
15:00  Break

15:30  Block II 
  • Jon Howe (GSK): 
    • Early genotoxicity screening of pharmaceutical candidates: Adaptive approaches and strategies to screening 
  • Amy Wilson, PhD (AstraZeneca): 
    • Development, validation, and implementation of a high content genotoxicity assessment screen 
  • Rob Smith, MSc (Covance): 
    • Genetic toxicology screening: A Covance perspective 
17:00  Break -- Enjoy the beautiful Rudding Park grounds; play a quick round of golf or catch a movie in the private cinema.

19:00  Dinner and Drinks
About the Metabolism Lab Tour

The metabolism laboratory facility at Covance in Harrogate has been completely redesigned, renovated and expanded, providing more than 300m2 of space. 

The new lab includes:
  • an increased QWBA footprint
  • a larger analytical suite (co-located with our bioanalysis services)
  • a 50% capacity increase, providing us with the ability to offer all 13 transporter assays onsite
Accommodations, Meals and Cost
  • The symposium is free and includes two lunches and dinner. 
  • If you choose to stay at Rudding Park, breakfast will be included in your room price. Rudding Park is offering a Covance rate; mention Covance when you contact the hotel (ph: 01423 844822; email)
  • Register today to ensure a spot; attendance is limited. 
Getting Around

Rudding Park Hotel, Follifoot, Harrogate, North Yorkshire HG3 1JH

The Leeds Bradford airport is about 30 minutes from Rudding Park. 

Both the Harrogate Railway Station (3 miles) and the Pannal Railway Station (2.5 miles) are within a 5-minute drive of the estate. 

Downtown Harrogate & Covance Laboratories: 
The estate is about 15 minutes from downtown Harrogate and the Covance facilities. 
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Getting Around
  • Address: Rudding Park Hotel, Follifoot, Harrogate, North Yorkshire HG3 1JH
  • Airport: Leeds Bradford (30 minutes)
  • Train: Harrogate Railway Station (3 miles; 5 minutes)
  • Train: Pannal Railway Station (2.5 miles; 5 minutes)  
  • Downtown Harrogate & Covance Laboratories: The estate is about 15 minutes from downtown Harrogate and the Covance facilities. 
Hotel Breakfast

09:00  Block III
  • Will Eborall, PhD (Covance): 
    • Fit for purpose LC-MS analysis: A CRO perspective 
  • Russell Mortishire-Smith, PhD (Waters): 
    • Technological advancements in screening platforms for metabolite data access and evaluation
  • Jatin Verma, PhD (Covance): 
    • Automated micronucleus analysis: Image analysis and flow cytometry 
10:30  Break 

11:00  Block IV
  • Alvaro Cardenas, PhD (UCB): 
    • Blood brain barrier studies in CNS drug discovery projects: Integration and strategies to maximise value
  • Andres Olivares, PhD (Roche): 
    • The use of PBPK and PK/PD strategies to aid candidate selection in drug discovery and early development 
  • Alex Cayley, PhD (LHASA): 
    • In silico predictions for genotoxicity: Current applications and future perspectives  
Noon  Farewell Lunch

13:15  Metabolism Covance Lab Tour - optional
Diary, Speakers & Topics
3-4 October 2018, Harrogate, UK
3 October, Wednesday

4 October, Thursday

Unless otherwise noted, all activities occur at Rudding Park.